Do stress factors alter DNA methylation during aging?

 

DNA methylation alterations are also known to occur as people get older and are linked to aging-related disorders. As a result, it appeared plausible that stress's effects on aging-related disease were mediated in part by alterations in DNA methylation generated by glucocorticoid receptor activation.

Changes in DNA methylation are significantly linked to ageing. In a wide range of animals ranging in complexity from yeast to humans, DNA methylation and epigenetic changes have been directly related to lifespan.

Stress can cause changes in DNA methylation, which can affect gene expression and so contribute to disease phenotypes. Stress in childhood, such as maltreatment and stress-related diseases, has long-term impacts on methylation that can endure into adulthood.

In humans, age has become the primary risk factor for various diseases, since many genes appear to show altered expression during the aging. altered expression in response to internal and external environmental stress.


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